The film is about Radhe (Salman Khan) who is a hardcore gangster. A sharpshooter with a sharp brain, he works for mafia leader Gani Bhai (Prakash Raj), but on his own terms. With no fear, Radhe single handedly eliminates Gani Bhai's enemies one by one; making more enemies in the process than he bargained for...He is shocked when a young and pretty lady named Jhanvi (Ayesha Takia Azmi) confesses her liking to him. Inspector Talpade's (Mahesh Manjrekar) lustful eyes fall on Jhanvi. He has no idea that she has a soft corner for Radhe.

Whether it's the Golden Gang or Data Pawle's Gang; everybody wants the biggest piece of Mumbai and the only way to get it is to eliminate who ever stands in their way. As Mumbai goes under a dangerous gang war, Commissioner Ashraf Khan vows to make the city free of crime and starts a campaign by catching 200 criminals in a single day.

It's a free for all with gangsters from rival gangs out to get each other and the police out to get all of them. And in a surprising twist, Radhe becomes the most wanted man in Mumbai.

Radhe is stuck in a situation where the gangsters want him dead because he knows too much while the police want him alive because they're desperate to know what he knows.